Recreating biochemistry: Over the last million years, Nature has found many powerful solutions to medical diagnostic, targeted drug delivery, and green chemistry. It did so by evolving molecular machines that perform these tasks efficiently, using minimal energy and generating environmentally benign waste products. The LBN’s main task is to recreate mimics of these complex molecular machines using “simple” biopolymer such as DNA. This allows us to uncover the design principles of natural nanomachines that perform, for example, molecular diagnostic and targeted drug delivery in living organisms.